The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
I Accidentally Saw My MIL in a Nightshirt on a Phone, but to My Shock, It Wasn’t Her or Her Husband’s Phone
I Accidentally Saw My MIL in a Nightshirt on a Phone, but to My Shock, It Wasn’t Her or Her Husband’s Phone
Jocelyn is enjoying a big family holiday when she accidentally sees racy pics of her MIL on a phone. As if that wasn’t bad enough, the owner of the phone then comes looking for the device, and it’s the last person she expected!
There are some things you just can’t unsee. I had one of those moments recently, during an annual family get-together at my in-laws’ cottage.
A bunch of us gather here every summer, including my parents and other relatives. We usually have a great time, but this year, I accidentally exposed a huge secret. The fallout almost destroyed us all.
A cabin on a lakeshore | Source: Pexels
So there I was, curled up in the old armchair in the corner of the living room, trying to fend off a nasty headache. Everyone was either cleaning up after dinner or preparing for our traditional board game night.
We had a rule: all phones went into a small wooden box during game time to ensure we all stayed present. The box was sitting right next to me, and I was using the lull to rest a bit after the games.
That’s when it happened.
A small wooden chest | Source: Pexels
One of the phones in the box buzzed. No big deal, right? But then it buzzed again. And again. Curiosity got the better of me.
I reached for the buzzing phone, trying to remember if we had any rules about checking messages. Pretty sure we didn’t, so I figured it couldn’t hurt.
The screen lit up as I picked it up. The wallpaper was a generic sunset, nothing special. But the notifications… I wish I hadn’t looked.
Woman staring at a phone in shock | Source: MidJourney
There, right on the screen, was a photo of my MIL, Mandy, in lingerie. My heart skipped a beat. I mean, she’s a classy lady, always so put-together, and there she was, posing like a Victoria’s Secret model.
I thought for sure it was Dean, my FIL’s phone. They’ve been married forever, so maybe they had their ways of keeping things spicy. Gross, but whatever.
But before I could even process that thought, my dad walked into the room, looking like he’d lost something. He went straight to the box, glanced inside, and frowned.
A mature man frowning | Source: MidJourney
“Hey, have you seen my phone?” he asked, scanning the room.
I held up the buzzing phone, trying to keep my face neutral. “This one?”
He grinned. “Yeah, that’s mine.”
Wait, what? My brain couldn’t keep up. My dad’s phone? I felt like I was in a bad soap opera.
He grabbed the phone from my hand and his eyes widened as he saw the screen. Without another word, he stormed into the kitchen. I followed him, feeling like I was floating outside my own body.
A woman in shock | Source: Pexels
In the kitchen, Mandy was washing dishes, humming softly to herself. My dad didn’t waste a second.
“Stop doing this! Stop sending these pictures!” he snapped.
She spun around, dropping a plate that shattered on the floor. Her face turned a shade of red I didn’t think was possible.
Maybe I should’ve waited to overhear more of the conversation, but that’s just not the type of person I am. Instead, I rushed right in there, determined to get answers.
“What’s going on?” I blurted out, stepping into the room.
A woman peering around a door | Source: Pexels
Both Dad and Mandy froze, like deer caught in headlights. They stared at me before exchanging a guilty look.
“Everything is fine, honey,” Mandy stammered. “It’s just a misunderstanding.”
“I don’t think so,” I replied, crossing my arms. “I saw the pictures.”
Dad sighed and rubbed his forehead. “I’ll explain everything.”
He took my hand and led me upstairs to one of the bedrooms. My mind was racing, trying to piece together what was happening.
“Look,” he began, sitting me down on the edge of the bed. “Mandy and I knew each other when we were younger.”
A tense mature man | Source: Pexels
“She was in love with me,” he continued, “but I didn’t feel the same. I met your mom, and everything between us ended. Or so I thought.”
I couldn’t believe what I was hearing. This was insane.
“When you and Dylan got married, and I saw Mandy again… it was surreal. We decided not to tell anyone about our past together. But then the pictures started.” Dad hung his head. “At first, I thought it was a one-time thing, but then it kept happening. Today was the last straw.”
“This is crazy,” I said, my voice barely a whisper.
A shocked woman | Source: Pexels
“I know, and I’m sorry you had to see that,” he said, his eyes full of regret. “But you need to understand, it’s over. It’s been over for a long time. Your mother is the love of my life, and nothing will ever change that.”
I took a deep breath, trying to steady myself. “What do we do now?”
“We confront this together, as a family,” he said firmly. “No more secrets. We’ll talk to her and make sure this stops for good.”
I was still reeling from everything Dad had told me as we headed back downstairs.
A wooden staircase | Source: Pexels
The whole thing felt surreal like I was trapped in some twisted reality show. My dad’s affair with Mandy from decades ago, her unrequited love, and now these scandalous photos — my head was spinning.
The rest of the family was gathered in the living room, sensing something was up. Mandy was nervously picking at a thread on her sweater, while Dean looked concerned, his eyes darting between us.
“We need to talk,” my dad announced, breaking the tense silence. “All of us. Now.”
“What’s this about?” Dean asked, his voice laced with worry.
A mature man | Source: Pexels
Mandy’s face paled as she glanced at my dad. “Please, not here. Not in front of everyone.”
“No,” I said, surprising even myself with the firmness in my voice. “This needs to be out in the open.”
My dad nodded, taking a deep breath. “It’s about the photos, the ones you’ve been sending to me.”
Dean’s eyes widened in shock. “What photos? What’s he talking about?”
Mandy’s shoulders slumped, and she let out a shaky breath. “I… Joseph and I dated before I met you. I’ve been sending him pictures. Inappropriate pictures. It was a mistake. I thought… I don’t know what I thought.”
Regretful mature woman | Source: Pexels
“You thought it was okay to do this?” I couldn’t keep the anger out of my voice. “To send those photos to my dad? How could you?”
Dean looked like someone had punched him. “I can’t believe this. Why, Mandy? Why would you do something like this?”
Tears welled up in Mandy’s eyes. “I was trying to hold onto something that was never really there. I made a mistake, a terrible mistake.”
“A mistake?” Dean echoed, his voice shaking with hurt. “This is more than a mistake. This is betrayal.”
Angry mature man | Source: MidJourney
My dad stepped forward, his expression serious. “We need to address this as a family. Mandy, you need to stop this behavior immediately.”
She nodded, wiping away her tears. “I know. I’m so sorry. I’ll do whatever it takes to make things right.”
We spent the next hour discussing what to do next. My dad was adamant that we needed a clear plan to move forward.
“We need to ensure this never happens again. Mandy, you need to seek help. Therapy, counseling—whatever.”
A sad mature woman | Source: Pexels
“I will,” she agreed, her voice small but determined. “I’ll get help. I don’t want to hurt this family any more than I already have.”
The weight of her words settled over us, and for a moment, there was only silence. Then Dean spoke, his voice heavy with emotion. “I need time to process this. But I want us to work through it. For our family.”
We all nodded, the gravity of the situation pulling us together. It wasn’t going to be easy, but we had to try.
Later that evening, after things had calmed down, my mom arrived.
Smiling mature woman | Source: Pexels
She’d been out for a walk, blissfully unaware of the storm that had erupted in her absence. We sat her down and explained everything.
Her reaction was a mixture of shock, sadness, and resolve. “We’ll get through this,” she said, holding my dad’s hand. “We’re a family, and we’ll face this together.”
The next few days were a blur of emotions as we all tried to process what had happened. There were a lot of difficult conversations, tears, and attempts at understanding.
Mandy started seeing a therapist, and slowly, we began to pick up the pieces.
Mature woman speaking to her therapist | Source: MidJourney
It was a long road to healing, but for the first time in a long while, it felt like we were all moving in the right direction. No more secrets, no more lies—just the truth, as painful as it was, and the hope that we could rebuild what had been broken.
Would you have exposed the secret if this happened to you?
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