One of the most remarkable changes in human evolution is the loss of our tails, a transformation that occurred around 25 million years ago. This pivotal shift not only altered the trajectory of our species but also marked a significant moment in the evolutionary history of primates. While scientists have long speculated on why humans lost their tails, the genetic cause has remained elusive—until now. A recent study published in Nature has finally uncovered the genetic factors responsible for this evolutionary change.
The Quest to Understand Tail Loss
The journey to unravel the mystery of human tail loss began in an unexpected way. Bo Xia, a graduate student at New York University, was inspired to investigate the origins of the human tailbone after injuring his own coccyx. This personal curiosity led Xia and his team to embark on a groundbreaking scientific investigation.
Through careful research, the team focused on the TBXT gene, which plays a crucial role in regulating tail length in various species. Their research revealed a unique genetic mutation within this gene, providing a major breakthrough in understanding human evolution.
The Role of Jumping Genes
A key aspect of this discovery lies in the role of Alu elements, often called “jumping genes.” These genetic elements, specific to primates, can move within the genome and cause significant changes. The researchers found that Alu elements inserted themselves into the TBXT gene, triggering a chain reaction that led to the loss of our tails.
This insertion activated a process known as alternative splicing, where RNA molecules are cut and restructured, which ultimately led to the deletion of a crucial exon. This change altered the structure and function of the resulting protein, leading to the tail loss seen in humans.
Validation Through Mice Studies
To confirm their findings, the researchers engineered laboratory mice with the same genetic mutations found in humans and apes. These genetically altered mice lost their tails, providing compelling evidence that the identified mutation plays a crucial role in the absence of tails in humans and other primates.
However, the study also uncovered a downside to tail loss: an increased risk of neural tube defects, such as spina bifida. This finding highlights the complex balance between evolutionary benefits and potential genetic trade-offs.
The Broader Implications
This discovery has profound implications not just for understanding human evolution, but also for human anatomy and health. The loss of our tails was not a random event but a genetic adaptation with lasting consequences. It illustrates the complex relationship between genetic changes and the way they shape our physiology over time.
As we continue to study our evolutionary past, these findings remind us of the intricate process of natural selection and genetic innovation that has shaped humanity. This breakthrough also underscores the power of scientific inquiry in uncovering the mysteries of our origins, offering insight into the past that can help us understand our future.
The identification of the genetic reasons behind tail loss is a testament to the persistence of scientific exploration and the ongoing quest for knowledge about our evolutionary journey.
‘American Pickers’ Frank Fritz put under guardianship – things started going downhill after bad engagement – Latest news!
We occasionally follow paths in life that we never would have imagined. Although Frank Fritz was a well-liked character on television, he was going through a lot in his personal life.
This is his tragic tale…
Longtime partner of Frank Fritz was Diann Bankson. His tumultuous split from her resulted in his drinking, unemployment, and even a medical emergency. Although the two are now permanently apart, their time spent together left a lasting impression on them both.]
At the age of 25, Frank Fritz, the host of “American Pickers,” first laid eyes on Diann Bankson. The pair intermittently dated before being engaged in 2017. They moved in together after purchasing an Iowa farmhouse a year later in 2018.
Their relationship, however, soured in November of that year when Bankson claimed to have “walked in” on Fritz and “caught him in bed with another woman.”
Fritz disclosed in an interview that Bankson had cheated on him and that he was even reminded of her “betrayal” by a tattoo. However, he declared his desire to wed her.
“I had planned to get married, had purchased a house and a very expensive ring, and was shocked to learn that my fiancée had been seeing someone else for the previous 2.5 years,” Fritz remarked.
Fritz stated, “She’s the cheater, which is why I got a tattoo saying ‘Once a cheater, always a cheater.’” He said that the tattoo was meant to act as a reminder to never do “the same mistake again.” And that Bankson had “cost” him a lot of money, he said.
He started drinking to heal his broken heart. That’s how he handled his heartbreak, he claimed. He lost a lot of weight as a result of this as well. “I gave it a good shot,” remarked Fritz. I made an attempt to drown her.
He overcame his drinking issue, but because the last relationship with Bankson had “stung hard enough,” he made the decision to put off dating for a while.
Following the split, he had losses in his career as well. The Sun claims that after March 2020, he stopped hosting History Channel’s “American Pickers.”
Fritz gave an explanation for his absence, saying that he intended to return to the show after the scar from his back surgery healed. “I would like to return to the show,” Fritz remarked. Now that I’m fully recovered, I’m prepared to resume my role on the show.
Fritz claimed there had been no definitive decision made by the show regarding his return. He said, though, that a showrunner had given him a call and assured him that he would return to the screen.
Despite Fritz having worked on the show for ten years, TMZ claims that the show has “no plans” to employ him as a host once more.
In addition to not returning to his show, Bankson’s ex-boyfriend Eric Longlett, an engineering administration manager, made his debut. She gushed about how fortunate she was to be with him in posts about him on social media.
“He took me to see Elton John’s Yellow Brick Road Farewell Tour,” she captioned a photo of herself and Longlett together at the concert. I’m a fortunate woman. Love you, sweetie. oxo
Fritz was hospitalized on July 4, 2022, following a stroke. After finding him on his house floor, his companion had phoned for assistance. The 911 call in which his friend stated, “He might be seizuring, I’m not sure,” was obtained by The US Sun.
Bill Fritz, Fritz’s father, told the reporters that his son was healing nicely and getting better every day.
His recuperation was not as complete as the physicians had hoped, though. After being discharged from the hospital, he was placed under guardianship and sent to a nursing home.
On August 18, 2022, his “longtime friend” reportedly filed an emergency appointment for temporary guardianship and conservatorship on his behalf, which was subsequently approved.
The bank was designated as his conservator to manage his finances, and his friend was named as his guardian.
In its capacity as his conservator, the bank would manage all of his care facility bills, including daily costs, health insurance, maintenance, and property tax payments. The bank would have to make sure he could get to events and doctor’s visits in a suitable manner.
In addition to being “in decision-making since the stroke,” his friend’s guardianship required that he submit a “initial care plan” for the patient.
In order to achieve this, his guardian would have to make decisions about his living situation, place of residence at the time, health, and medical requirements. They would also need to arrange for him to participate in activities, maintain communication with him and his loved ones, and pursue romantic relationships. It would also be expected of him to provide an annual report as his guardian.
His health was getting worse, according to his papers, and it was making it more difficult for him to make wise decisions for himself, “without which physical injury or illness may occur.”
Documents revealed that he was unable to “make, communicate, or carry out important decisions concerning his own financial affairs,” indicating that his condition was far worse than previously believed.
His guardian will have to make decisions on his behalf as he heals and is able to “receive treatment for his injuries.”
The court determined that Fritz needs a guardian in order to prevent additional harm to his health. The court decided that “appointing a guardian and conservator is necessary to avoid immediate harm to him.”
This story really breaks my heart. We send Frank Fritz our best wishes for wellness and recovery.
Tell your friends and relatives about this so they can pray for the well-being of their beloved TV show presenter and learn what happened to him.
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