The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
A Proud Father’s Joy: Hazel Moder at Cannes Film Festival
A Lovely and Encourageing Evening
Hazel Moder, Julia Roberts and Danny Moder’s talented daughter, made an unusual appearance at the renowned Cannes Film Festival in July. Even though the family often keeps their children out of the spotlight, Hazel attended the function to support her father’s choreography for the movie “Flag Day,” starring Sean Penn. And trust me when I say that she was the star of the show thanks to her amazing attractiveness.
Obtaining the Best Genetic Information
That Hazel drew notice at the festival makes sense. With her gorgeous blonde hair, striking blue eyes, and laid-back personality, she surely inherited some of her parents’ best traits. While some believe she has her mother’s nose, others notice a strong resemblance between her and her gorgeous father. Either way, she was obviously the center of attention.
A Chic Display of Grace Hazel’s choice of attire further accentuated her attractive appearance. She wore a beautiful yellow lace gown that was elegantly paired with black Mary Jane pumps. The hairstyle she wore emphasized her youthful beauty. The modest makeup brought out her natural features, giving her an older-than-actual air of refinement. She truly radiated grace and elegance; she was a young woman in every sense of the word.
A Satisfied Father’s Remark
Danny Moder could not control his pride as he spent the entire evening by Hazel’s side. The father-daughter duo was so loving and devoted that the atmosphere was one of excitement and happiness. It was amazing to witness their friendship and the joy they shared.
Building Grounding and Humility
In a culture when being famous often means losing one’s privacy, Julia Roberts and Danny Moder have made a conscious effort to keep their children out of the spotlight. Despite having a huge career and wealth, Roberts stays grounded and modest. This perspective includes her children as well.
Roberts admitted in an interview with Harper’s Bazaar that her children first struggled to comprehend her fame. As parents, Roberts and Moder acknowledge that they have no idea what it’s like to grow up in today’s world. When their children ask questions, Roberts honestly admits that she doesn’t know enough about their generation, but she makes a commitment to research it and discover the answers. Seeing parents who are willing to learn with their children and humble in their guidance is heartening.
A Ordinary Life Outside of Hollywood’s Glamour and Glamor
Their reasonable and grounded parents keep Hazel and her siblings out of the spotlight. Ensuring their well-being and providing them with an opportunity to lead normal lives away from the glitz and glitter of Hollywood are top priorities for Roberts and Moder. Hazel and her siblings get to experience the beauty and simplicity of an ordinary childhood instead of being thrust into the fast-paced and usually superficial world of the entertainment industry.
The fact that Julia Roberts and Danny Moder prioritize their children’s happiness and health above all else in a culture that sometimes places an excessive importance on celebrity and wealth is heartening. By keeping their children out of the spotlight, they are teaching their children the value of having humble and grounded lives. Furthermore, it’s evident from what we saw of Hazel Moder at the Cannes Film Festival that she is an exceptional young woman ready to take on the world with style and grace thanks to her parents’ love and care.
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