The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
“This Woman Had 4 Kids,” Blake Lively Shocks People in a Skin-Tight Suit
Blake Lively recently captivated audiences with her stunning post-maternity figure, making a striking appearance in a form-fitting outfit that highlighted her impressive physique. Fans and fashion enthusiasts alike were astounded by Lively’s shape.
Blake Lively arrived at the Deadpool & Wolverine premier.
Blake Lively made a stunning entrance at the world premiere of her husband Ryan Reynolds‘ latest film, Deadpool & Wolverine. Embracing a theme that paid tribute to his character, Lively wore a Versace bodysuit. The striking red outfit featured long sleeves and an off-the-shoulder design, embellished with intricate patterns, perfectly capturing a superhero essence.
She complemented her bold look with a high ponytail, adding a sophisticated touch. Lively’s choice of attire not only celebrated the film but also demonstrated her flair for fashion and ability to stand out on the red carpet.
Fans of the movie speculated the same thing.
Fans of the movie speculated excitedly after seeing the trailer, which features a mysterious Lady Deadpool character fully clad in a red suit. The character’s blonde hair and the red-and-black suit matching Deadpool’s sparked curiosity about the actress behind the mask.
Blake Lively’s choice of outfit at the premiere, reminiscent of the Lady Deadpool costume, fueled fan theories that she might be the one playing the enigmatic role.
Fans were astonished by her looks.
Fans were shock by Blake Lively’s appearance. Comments flooded social media, with one fan exclaiming, “Blake looks amazing, this woman had 4 kids!” Another humorously remarked, “Blake looks amazing! But after four kids, how does she go to the bathroom?” referencing her sleek, one-piece suit. Admirers continued to express their awe, with one stating, “Blake Lively is so insanely perfect and beautiful.”
Her red carpet look not only showcased her incredible post-maternity physique but also left fans in awe of her elegance and beauty.
In a stunning display of grace and confidence, Salma Hayek, 57, was recently hailed as the epitome of elegance at a high-profile event. Proudly embracing her natural gray hair, the actress captivated onlookers and fans alike, redefining beauty standards with her timeless charm.
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