The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Boiling Eggshells: Save Money and Help the Environment
Ever wonder how many eggshells people throw away in the trash? It really is a lot! However, did you realize that boiling these inconsequential-looking shells can really result in financial savings? It’s also a fantastic technique to lessen trash and contribute to environmental preservation. Now let’s explore the several advantages of reusing eggshells!
Eggs: A Powerhouse of Nutrition
In addition to being tasty and adaptable, eggs are also a great source of important nutrients. They include excellent sources of lipids, proteins, vitamins, and minerals, making them a full meal. About 6 grams of protein may be found in one egg, which is an essential component for sustaining muscle mass and meeting your daily dietary requirements. Protein is essential for maintaining a healthy immune system in addition to being necessary for muscles.
Cracking the Secret Code of Eggshells
Let’s now discuss eggshells. Though many of us just toss them out without giving them any thought, these “throwaways” actually have a lot to give. The main component of eggshells is calcium carbonate, which is also a component of antacid drugs. This implies that they may be a fantastic supply of calcium, a mineral that is necessary for healthy bones.
Eggshells may readily have the calcium extracted from them by boiling them, which makes for an inexpensive, natural, and DIY calcium supplement. Because strong bones become ever more dependent on calcium as we age, this is especially advantageous for elderly folks.
Easy Steps for Recycling Eggshells
Are you prepared to start maximizing your eggshells and cutting costs? Here’s a short, detailed how-to:
Gather and tidy: After giving empty eggshells a thorough rinse, let them air dry.
Crush the shells: Using a food processor or mortar and pestle, break the shells into little pieces once they have dried.
Bring the crushed shells to a boil by putting them in a pot with water and covering them. Simmer it for ten to fifteen minutes.
Strain and cool: To get rid of any shell bits, strain the liquid after it has simmered. Let cool completely before putting it in a fresh bottle or jar.
Utilize and delight in: You can now utilize your own calcium supplement. Take one tablespoon of the liquid every day, stir it into your preferred drink, or incorporate it into your meals.
Reduce Spending, Protect the Environment, and Boost Your Health
Not only is boiling eggshells a cost-effective decision, but it’s also an environmentally beneficial one. You can obtain a natural calcium supply that promotes bone health and general wellbeing by recycling these shells. Thus, keep in mind to save and repurpose the eggshells the next time you crack open an egg!
Leave a Reply